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MOTS‑C 10 mg (Mitochondrial‑derived peptide)
$125.00
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Frequently Asked Questions
What is MOTS‑C?
A 16‑amino acid mitochondrial‑derived peptide regulating metabolism and stress adaptation.
Is MOTS‑C naturally occurring?
Yes, it is encoded in human mitochondrial DNA.
What are its main research uses?
Studies on metabolism, insulin sensitivity, exercise physiology, and aging.
How should MOTS‑C be stored?
Refrigerated at 2–8 °C; long‑term storage at −20 °C.
What is the shelf life of MOTS‑C?
When stored properly, MOTS‑C has a shelf life of 24 months in lyophilized form. Once reconstituted, it should be used within 2–4 weeks if refrigerated.
Is MOTS‑C approved for human use?
No, it is strictly for research purposes.
Overview
MOTS‑C is a mitochondrial‑derived peptide (MDP) encoded within the 12S rRNA gene of mitochondrial DNA. Unlike most peptides encoded by nuclear DNA, MOTS‑C originates from the mitochondrial genome, making it unique in peptide biology. It regulates metabolic homeostasis, enhances insulin sensitivity, and supports cellular adaptation to stress.
History
Discovery: First described in 2015 as part of a new class of mitochondrial‑derived peptides.
Significance: Revealed that mitochondria can encode bioactive peptides, expanding the known signaling role of mitochondrial DNA.
Research Milestone: Identified as a regulator of AMPK activation and glucose metabolism.
Research Findings
Metabolic Regulation: Activates AMPK, promoting glucose uptake and fatty acid oxidation.
Insulin Sensitivity: Improves systemic insulin response in preclinical models.
Exercise Adaptation: Endogenous MOTS‑C levels rise during physical activity, supporting endurance.
Anti‑Obesity Potential: Shown to prevent diet‑induced obesity in animal studies.
Longevity Link: Genetic polymorphisms in MOTS‑C are associated with human lifespan.
Molecular Structure
References
Mohtashami Z. MOTS‑c in Human Aging and Age‑Related Diseases. 2022.
Zheng Y. MOTS‑c: A Promising Mitochondrial‑Derived Peptide for Therapeutic Exploitation. Frontiers in Endocrinology. 2023.
PubChem Compound CID 146675088 — MOTS‑C.
ChemicalBook MOTS‑C Profile, 2026.
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